Gender matters in the brain/bone axis. APOE4, the Alzheimer’s risk gene, silently undermines bone quality in women
Peer-Reviewed Publication
Updates every hour. Last Updated: 31-May-2026 17:15 ET (31-May-2026 21:15 GMT/UTC)
Scientists at the Buck Institute for Research on Aging, along with collaborators at UC San Francisco, have discovered that APOE4, the most common genetic risk factor for Alzheimer’s disease, causes bone quality deficits specifically in female mice, through a mechanism that is invisible to standard imaging and can emerge as early as midlife.
SAN DIEGO, APRIL 13, 2026 ― Jennifer Wargo, M.D., professor of Surgical Oncology and Genomic Medicine at The University of Texas MD Anderson Cancer Center, has been elected to the 2026 class of Fellows of the American Association for Cancer Research (AACR) Academy in recognition of her pioneering work to define interactions between the microbiome, cancer biology and treatment response.
Scientists at Sanford Burnham Prebys Medical Discovery Institute and an international team of collaborators discovered a new rare genetic disease that interferes with brain development.
The researchers published findings in Human Genetics and Genomics Advances that identify the faulty mutated gene. By exploring the biochemical consequences of the mutation, the investigators also showed that this typo in the genetic code interferes with normal cellular function.Advanced liver disease (ALD) occurs when significant scarring causes the liver to lose function. Patients with ALD often have serious health challenges but have limited access to palliative care that could improve their quality of life. A new multicenter trial led by Manisha Verma, MD, and Victor Navarro, MD, at Jefferson Einstein Philadelphia Hospital demonstrates a new approach that could potentially transform access to palliative care for patients with ALD and address a major care gap.