Researchers at VCU Massey Comprehensive Cancer Center were recently awarded a $2.5 million R01 grant from the National Cancer Institute. The five-year grant will allow Massey to evaluate the efficacy of TROP2 targeted antibody-drug conjugates (ADCs) to further enhance therapeutic benefits in both breast and pancreatic cancer care.

 

Massey researchers, led by principal investigator Chuck Harrell, Ph.D., member of the Cancer Biology research program at Massey and professor in the Department of Pathology at the VCU School of Medicine, will look to define what enables responses and resistance to ADCs in order to identify predictive biomarkers and establish therapeutic strategies to optimize TROP2-targeted ADC efficacy in both triple-negative breast cancer (TNBC) and pancreatic ductal adenocarcinoma (PDAC).

Researchers at King’s College London have developed a new mathematical framework to test whether AI systems that appear to explain their decisions are genuinely transparent.

Researchers at the Icahn School of Medicine at Mount Sinai have found that small populations of pancreatic cancer cells can create localized immune-protective niches that shield tumors from immune attack. The finding could open new avenues for making immunotherapy more effective against one of the deadliest forms of cancer.

A new Scientific Statement released today by the Endocrine Society highlights the benefits of obesity treatment beyond weight loss, including improvements in overall health and reducing the risk of conditions such as heart disease, sleep apnea and liver disease.

A clinical trial led by WashU Medicine researchers found that combining mental health coaching with medication optimization reduced post-surgery anxiety and depression in older adults.

This qualitative study found that physicians with life-threatening illness often experienced clashes in their professional and personal identities. This study’s results suggest that health care institutions should consider shifting from procedural to relationship-centered return-to-work policies and interactions during this critical time of transition to better support and retain physicians in the workforce.

These findings suggest that partner similarity for psychiatric disorders is substantial and includes both within- and cross-disorder patterns, suggesting assortative mating alongside other mechanisms that may generate similarity between coparents. Regardless of its underlying mechanisms, this structure contributes meaningfully to observed family-based heritability and prevalence and leads to clustering of familial disease risk with important societal and public health implications.