Excess fat accumulation in the liver can contribute to the development and progression of metabolic dysfunction-associated steatotic liver disease (MASLD), highlighting the need for new approaches to manage the condition. Now, researchers have found that hyodeoxycholic acid (HDCA), a bile acid, can reduce liver fat in mice while also identifying the biological pathways involved. The findings suggest that HDCA could help inform the development of new approaches to managing MASLD.

A simple change in when people eat may offer a promising new approach for Huntington’s disease, according to research led by Oregon Health & Science University.

In a 12-week pilot study, researchers found that people with early-stage Huntington’s disease were able to safely follow a form of intermittent fasting known as time-restricted eating, limiting food consumption to a six-to-eight-hour window each day. Participants avoided unintended weight loss and showed improvements in measures of disease severity; in a blood biomarker linked to nerve cell damage; and in cellular energy production.