A multicenter study of 2,746 patients with acute pancreatitis (AP) introduces ORACLE, an artificial intelligence model that predicts organ failure from CT imaging. The model achieved AUCs of 0.81–0.89, outperforming conventional scoring systems, and provided a median early warning of 3.5 hours before clinical onset. Its 97.2% negative predictive value may help clinicians stratify risk.A multicenter study of 2,746 patients with acute pancreatitis (AP) introduces ORACLE, an artificial intelligence model that predicts organ failure from CT imaging. The model achieved AUCs of 0.81–0.89, outperforming conventional scoring systems, and provided a median early warning of 3.5 hours before clinical onset. Its 97.2% negative predictive value may help clinicians stratify risk.

Scientists have developed a new fluorine-based tracer that can be tracked using magnetic resonance imaging (MRI) to monitor how quickly food moves through the gastrointestinal tract. The new method has so far been successfully tested in rats in a preclinical study, but it could eventually help diagnose gastrointestinal motility disorders or monitor treatment response. The study was published in Advanced Healthcare Materials.

A research team led by Prof. Hnin Yin Yin NYEIN from the Department of Chemical and Biological Engineering at The Hong Kong University of Science and Technology (HKUST) has developed a novel wearable device named "HELP" (heteromodal epidermal liquid-metal patch).

A single infusion of genetically corrected autologous hematopoietic stem cells can provide durable clinical benefit for patients with Wiskott-Aldrich Syndrome, a rare genetic disorder that impairs immune function and platelets function, exposing affected children from an early age to severe infections, bleeding episodes, eczema and autoimmune complications. The publication presents the outcomes of 27 patients treated with etuvetidigene autotemcel (etu-cel), an autologous gene therapy developed to correct the genetic defect underlying the disease. Patients were followed for at least 5.7 years, with some monitored for more than 13 years. Overall survival was 96% at both one and five years, while severe infections and moderate-to-severe bleeding events were markedly reduced following treatment. Among the adverse events observed, none were attributable to the gene therapy product, confirming a favorable risk-benefit profile.

The Royal Academy of Medicine of the Canary Islands has recognized a study conducted by researchers from Hospital Universitario de Canarias (HUC) and the University of La Laguna (ULL), and published in the International Journal of Molecular Sciences (IJMS), an open access scientific journal published by MDPI. The recognition highlights research conducted in the Canary Islands and disseminated through an open access publication.

A new review traces more than 70 years of microecology research in China, from early ideas about microbial balance to today’s work in precision medicine, sustainable agriculture and environmental restoration. The authors argue that combining artificial intelligence, synthetic biology and international collaboration could help turn microbiome science into practical solutions for human, animal and environmental health.