Recreating key features of the antibody factory in a dish
Peer-Reviewed Publication
Updates every hour. Last Updated: 28-Oct-2026 02:16 ET (28-Oct-2026 06:16 GMT/UTC)
Researchers at the University of Osaka developed a simple two-step culture system that turns human blood-derived B cells into germinal center-like B cells using CD40L, IL-4, and IL-21 in a specific sequence. The resulting cells closely resemble genuine human germinal center B cells and undergo somatic hypermutation. The platform provides a practical tool for studying antibody formation directly in human cells and may support future vaccine and autoimmune disease research.
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