A Duke University School of Medicine team found that β‑arrestin proteins, which regulate GPCR activity, can assemble into liquid-like clusters known as condensates both at baseline and near activated receptors. These droplet-like structures act as hubs that organize signaling molecules in space and time.

This Cystic Fibrosis Awareness Month, Children’s Hospital Colorado (Children’s Colorado) is highlighting a growing shift in care: starting cystic fibrosis treatment before birth to improve lifelong health outcomes and reduce hospital stays. Through a highly coordinated, multidisciplinary approach, Children’s Colorado’s Breathing Institute and Colorado Fetal Care Center teams have cared for 10 families through prenatal therapy for patients showing signs of cystic fibrosis in utero. To date, no other healthcare system in the United States has cared for this number of patients prenatally, positioning Children’s Colorado among the most experienced of its kind in the world.

The study, published in Communications Medicine, combines magnetic resonance imaging and simulation-based artificial intelligence to speed up brain analysis while maintaining a high level of accuracy.

The method avoids the use of real patient data for training, reduces bias, and could facilitate the implementation of these advanced techniques in hospitals, helping to shorten waiting lists and improve diagnosis.

Researchers are increasingly using EEG (electroencephalography) to investigate how caffeine affects the brain during sleep — and findings suggest the issue goes beyond simply “falling asleep.” According to Prof. Donata Kurpas of Wroclaw Medical University, caffeine may reduce slow-wave activity, a key marker of deep, restorative sleep, even when sleep duration appears normal. EEG analyses reveal that the brain can remain in a more “wakeful” state overnight, potentially impairing recovery despite the subjective feeling of good sleep. Scientists also emphasize strong individual differences in caffeine sensitivity linked to genetics, metabolism, age, stress, and fatigue. The findings suggest that caffeine’s stimulating effects may contribute to a cycle of daytime fatigue and poorer nighttime recovery, highlighting the importance of sleep quality — not only sleep length — in understanding caffeine’s impact on health.