Achieving direct α-heteroarylation of amides and esters under mild conditions, eliminating the need for transition metals
Peer-Reviewed Publication
Updates every hour. Last Updated: 25-Oct-2026 23:16 ET (26-Oct-2026 03:16 GMT/UTC)
Professor Qilong Shen's research group at the Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, developed an extremely mild and efficient new synthetic strategy. Under transition metal-free conditions, various α-heteroaryl amides and esters can be constructed in high yields simply by mixing zinc powder, α-bromoamides (or esters), and heteroaryl halides at room temperature. This not only greatly simplifies the reaction process but also provides a practical and green new method for the synthesis of related drug molecules and their skeletons. The article was published as an open access Research Article in CCS Chemistry, the flagship journal of the Chinese Chemical Society.
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