Antibiotics could trigger immune response through gut microbiome metabolites
Peer-Reviewed Publication
Updates every hour. Last Updated: 14-Dec-2025 18:11 ET (14-Dec-2025 23:11 GMT/UTC)
The microbes inside our bodies not only help break down food but also impact our health. Yet their precise influence is not always understood, especially in the presence of prescription drugs. Now, researchers in ACS Central Science report how one of the most abundant gut bacteria responds to tetracyclines, a class of commonly prescribed antibiotics. Newly characterized signals released by the bacterium could aid the host’s immune response, inhibit pathogens and restructure the gut microbiome.
Researchers at Okayama University have developed a novel photochemical macrolactonization that converts hydroxyaldehydes into macrolactones (ring sizes 7–21) using in-situ generated acyl bromide intermediates under purple LED light. This radical light-driven method bypasses conventional activating agents and opens a versatile, efficient pathway for constructing complex natural product frameworks—a promising advance for drug discovery and macrolide synthesis.
In International Journal of Extreme Manufacturing, researchers from Tsinghua University proposed a novel tip-based vibration carving processing method for shape-customized convex microstructures for the first time. Their work combined the advantages of tip-based machining and vibration texturing, showing great potential in the convex microstructure processing of customized functional surfaces. Such method will significantly expand the design boundaries of functional surfaces to address the challenges in thermal, electrical, acoustic, and optical fields.
Silicon anodes can greatly boost the energy density of all-solid-state batteries, but their large volume changes often cause contact loss with solid electrolytes. Using operando synchrotron X-ray micro- and nano-computed tomography, researchers at Ritsumeikan University directly visualized the 3D evolution of the silicon–electrolyte interface during charge and discharge cycling. They found that even as silicon expands and shrinks, the thin, solid-electrolyte layers remain adhered, preserving partial ion pathways and enabling stable operation.
While scientists have made significant progress in understanding how nerve cells transmit signals across their outer membranes, Marucho’s team is focused on what happens inside the cell, within the cytoskeleton. The cytoskeleton is a network of structures located within a cell’s cytoplasm that is composed of actin filaments and microtubules.
Previous research has underestimated the role of these structures in neuronal signaling. But Marucho’s research suggests that microtubules could act as miniature electrical wires, facilitating long-distance signal transmission.