Adenomyosis affects up to one-third of women of reproductive age and is linked to pain, heavy bleeding, and infertility. Researchers from Jiaxing University and Tongji University have developed a new laboratory “assembloid” model that mimics uterine tissue, published in SCIENCE CHINA Life Sciences. The model reveals that abnormal stromal cell subgroups may disrupt BMP and WNT signaling pathways, driving disease progression. This work provides a valuable tool for studying adenomyosis mechanisms and developing new treatments.

This study found interesting, complex and important interactive effects among meteorological factors and ambient air pollutants on influenza incidences in Huaian, China.

Researchers have uncovered a previously unknown mechanism that safeguards the chromosome ends from being mistakenly repaired by the cell. While DNA repair is vital for survival, attempts to repair the chromosome ends – called telomeres – can have catastrophic outcomes for cells. The research, published in Nature, increases the understanding of how cancer and certain rare diseases develop. It was led by researchers at Linköping University and the Institute of Cancer Research in the UK.

This study investigates the impact of synonymous gene recoding, specifically codon optimization (CO) and codon-pair optimization (CPO), on the properties of human ADAMTS13 protein. By comparing wild-type (WT) ADAMTS13 with CO and CPO variants, the researchers aimed to elucidate the cellular mechanisms underlying the biogenesis of these recoded proteins and their implications for therapeutic applications.