Targeted protein degradation has become one of the most promising strategies in modern drug discovery, enabling scientists to eliminate disease-causing proteins instead of merely blocking them. Now, researchers at CeMM, AITHYRA (both Institutes of the Austrian Academy of Sciences), and CeTPD have discovered that a single small molecule can recruit not one, but two independent protein disposal systems at the same time. This dual mechanism introduces a built-in redundancy that could make future degrader therapies more robust and less vulnerable to resistance. The findings, reported in Nature Chemical Biology (DOI: 10.1038/s41589-026-02224-y), expand the design principles of targeted protein degradation and open new avenues for more resilient medicines.

Researchers from The University of Osaka found that the zinc finger proteins RLF and ZFP292 play redundant roles in stabilizing the CoREST corepressor complex at gene promoters in embryonic stem cells. Deleting both proteins allowed the cells to differentiate, suggesting that they could be useful targets for maintaining stem cell quality.

For decades, the search for life beyond Earth has revolved around a key question: What molecules should scientists be looking for on other planets or moons? A new study suggests the more revealing clue may not be the molecules themselves, but the hidden order connecting them.

Scientists at the Stowers Institute for Medical Research and Helmholtz Munich have developed RegVelo, a new AI framework that predicts how cells acquire their identities and identifies the genetic regulators guiding those changes. Published in Cell, the study used zebrafish neural crest development to show RegVelo can uncover early drivers of cell fate, including regulators of pigment cell formation, and then support those predictions experimentally. The researchers also applied the framework across multiple biological systems, suggesting its value extends beyond neural crest cells as a broadly useful tool for studying how cells change over time. The team says the new model could pave the way for future cell therapy treatments.

Researchers develop light-induced Asp(D)-to-Ala(A) protein editors (LIDAPEs) which enable site-specific residue editing of endogenous protein in living cells, and lay the foundation for a new class of chemical biology tools.

Harbour porpoises were once found across a much wider area of the Baltic Sea than they are today, including regions where they are now rare or absent. This is shown in a new study that uses centuries-old Swedish newspapers to reconstruct past distribution patterns.