Today's children are absorbing screens at scales no previous generation has known, during the precise developmental windows when neural architecture is most malleable. A new Thought Leaders Invited Review in Brain Health offers a framework for understanding what that means. Michel Cuenod, Julio Licinio, and Kim Q. Do introduce the criticome: the complete ensemble of sensory, motor, social, cultural, and environmental experience integrated by the brain during critical periods from before birth through roughly age twenty-five. The synthesis grounds the term in six neurobiological mechanisms and reframes autism, schizophrenia, post-traumatic stress, and major depression as developmental rather than purely synaptic disorders.

Elli Theobald, University of Washington assistant professor of biology, aims to connect the biology concepts her students learn in class to real-world issues, something she hopes will help both retain students in the biology major at the UW and help non-majors in the class with their future careers. How common is it for educational materials — such as guidelines or test questions — to include connections to society? In a recent paper, Theobald and her team examined almost 3,000 science guidelines and assessment questions from 16 sources to answer this question. Of the approximately 200 elements — about 7% — that had real-world implications, many discussed ethics and public health issues. 

This year’s recipient of the Sobrato Prize in Neuroscience is Andrew Yang, PhD, whose research has reshaped scientific understanding of the blood-brain barrier and its role in brain health and disease. Yang is an investigator at the Gladstone Institute of Neurological Disease and an assistant professor of neurology and anatomy at the University of California, San Francisco. Launched in 2024, the Sobrato Prize in Neuroscience seeks to bridge the gap between discovery and the clinic, accelerating life-changing brain science with high potential for patient impact. It is awarded to scientists at Gladstone Institutes whose research has a particularly high potential to lead to new therapies for major brain diseases.

A recent review provides an overview of the purinergic receptor P2Y2 and its involvement in cancer-related processes. The article discusses how extracellular nucleotide signaling may influence tumor cell behavior and the tumor microenvironment, and evaluates the potential of P2Y2 as a biomarker and therapeutic target.