A new study published in Life Metabolism reports that a single post-meal blood biomarker, 1-hour postprandial SPARC (SPARC-1H), can predict who will benefit most from adopting a Mediterranean diet. The discovery provides one of the clearest examples to date of how precision nutrition can identify individualized dietary responses using a simple blood test rather than complex multi-omics models.

Lung cancer is the leading cause of cancer-related mortality worldwide. Elucidating the molecular programs that enable tumor cells to evade regulated cell death and anti-tumor immune responses is essential for developing effective therapeutic strategies. In this study, Wang and colleagues employ a series of genetically engineered non-small cell lung cancer mouse models, high-throughput lipidomics assays, and functional perturbation experiments to uncover how tumor cells adapt metabolically to escape ferroptosis and reprogram the tumor microenvironment for CD8⁺ T cell dysfunction.

Whether great minds think alike is up for debate, but the collaborating minds of two people working on a shared task process information alike, according to a study published November 25^th in the open-access journal PLOS Biology by Denise Moerel and colleagues from Western Sydney University in Australia.

The research by geobiologist Eric Boyd examines the impact of seismic activity on underground microbial communities.

Adipose tissue is a crucial energy-regulating organ in mammals, responsible not only for storing excess energy but also participating in body temperature maintenance and metabolic balance.

In a study now published in iScience, researchers from the University of Vienna (Austria), National Institute of Technology - Wakayama College (NITW; Japan), and Shimane University (Japan) present the largest cephalopod genome sequenced to date. Their analyses show that the vampire squid has retained parts of an ancient, squid-like chromosomal architecture, and thus revealing that modern octopuses evolved from squid-like ancestors.

Four major turning points around age nine, 32, 66 and 83 create five broad eras of neural wiring over the average human lifespan. Typical adolescent brain development lasts until our early thirties on average, when the adult era of neural wiring finally emerges.