Summary

CORNETO is a new computational tool that helps researchers combine different types of biological data with prior biological knowledge to map how molecules like genes and proteins interact inside cells.

By analysing different samples together at once, CORNETO shows which biological processes are common and which are unique across cell types and conditions. 

Researchers have used CORNETO to reveal shared and cell-specific pathways in disease research, e.g. to identify signalling pathways associated with chemotherapy resistance in ovarian cancer patients.

Researchers from Japan and France have successfully reconstituted the development of mouse egg cells, known as oocytes, from embryonic stem cells entirely in vitro, without the need for ovarian support cells. This new method offers researchers a powerful new platform to investigate the molecular mechanisms that control oogenesis, the process by which egg cells develop, and lays important groundwork for future applications in human reproductive biology.