Biology
Updates every hour. Last Updated: 20-Jun-2025 02:10 ET (20-Jun-2025 06:10 GMT/UTC)
Cracking the code of a worm's throat
Weizmann Institute of Science- Journal
- Proceedings of the National Academy of Sciences
How fungi strengthen their defenses - and how we could break through them
Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute -Peer-Reviewed Publication
An often-overlooked mechanism of gene regulation may be involved in the failure of antifungal drugs in the clinic. This has been discovered by a German-Austrian research team led by the Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (Leibniz-HKI). The study focused on the mold fungus Aspergillus fumigatus, which can cause life-threatening infections, especially in immunocompromised people. Targeted changes to the fungal RNA allow a better understanding of the molecular mechanisms, which are responsible for the development of resistance and the fungus' defense mechanisms against drugs.
It´s been long known that bacteria are becoming increasingly resistant to antibiotics. The risk of no longer being able to successfully treat bacterial infections is constantly increasing. Equally critical - although not in the public focus - is the resistance of fungal pathogens to antimycotics, which is exacerbated by the massive use of similar active ingredients in agriculture. This problem is reflected in alarming data: With over one billion infections and around 3.75 million deaths per year, fungal infections are a significant threat to humans - the trend is rising.
The treatment of fungal infections is currently based on a few groups of medical active substances such as echinocandins, polyenes, azoles or the synthetic molecule fluorocytosine. The team led by Matthew Blango, head of a junior research group at the Leibniz-HKI, used the known mode of action of fluorocytosine on A. fumigatus as the basis for the investigation of the development of fungal resistance.
- Journal
- Nucleic Acids Research
How marlin and sardines outsmart each other
Technische Universität Berlin – Science of IntelligencePeer-Reviewed Publication
- Journal
- Communications Biology
- Funder
- Deutsche Forschungsgemeinschaft
Unclogging the immune system
Weizmann Institute of ScienceAs we age our bodies are flooded by aging, or senescent, cells, which have stopped dividing but, instead of dying, remain active and build up in body tissues. Recent studies have shown that getting rid of these cells might delay age-related diseases, reduce inflammation and extend lives. Despite the great potential, however, there is currently no drug that can target these cells directly and efficiently.
Now, Weizmann Institute of Science researchers suggest an alternative approach. In a new study published in Nature Cell Biology, they reveal that senescent cells build up in the body by clogging up the immune system, thereby preventing their own removal. The scientists demonstrated in mice how to unclog this blockage using immunotherapy, the new generation of treatments that is revolutionizing cancer therapy. These findings could pave the way for innovative treatment of age-related diseases and other chronic disorders.
- Journal
- Cell Biology
Medicinal Plant Biology successfully indexed in Web of Science: Emerging Sources Citation Index (ESCI)
Maximum Academic PressBusiness Announcement
- Journal
- Medicinal Plant Biology
Innovative technology enables the simultaneous delivery of two drugs to attack the tumor
Tel-Aviv UniversityPeer-Reviewed Publication
Researchers at Tel Aviv University have developed a new platform using polymeric nanoparticles to deliver drug pairs to specific cancer types, including skin cancer and breast cancer. The researchers explain that having both drugs arrive at the tumor site together significantly amplifies their therapeutic effects and safety profiles.
- Journal
- Science Advances