Gram-negative bacteria are highly resistant to antibiotics due to their robust outer membrane (OM), which is built and maintained by specialized molecular machinery. In a recent study, researchers from Japan uncovered how a small protein called LptM stabilizes the LptDE complex, which is essential for proper OM function. Their structural and biochemical analyses revealed how LptM fine-tunes the structure of LptDE during maturation, offering key insights that may support future antibiotics targeting this complex.

The evolutionary success of our species may have hinged on minute changes to our brain biochemistry after we diverged from the lineage leading to Neanderthals and Denisovans about half a million years ago 

Two of these tiny changes that set modern humans apart from Neanderthals and Denisovans affect the stability and genetic expression of the enzyme adenylosuccinate lyase, or ADSL. This enzyme is involved in the biosynthesis of purine, one of the fundamental building blocks of DNA, RNA, and other important biomolecules. In a study to be published in PNAS, researchers from the Okinawa Institute of Science and Technology (OIST), Japan and the Max Plank Institute for Evolutionary Anthropology, Germany have discovered that these changes may play an important role in our behavior, contributing new pieces to the great puzzle of who we humans are and where we come from. “Through our study, we have gotten clues into the functional consequences of some of the molecular changes that set modern humans apart from our ancestors,” says first author Dr. Xiang-Chun Ju of the Human Evolutionary Genomics Unit at OIST.  

Scientists at St. Jude Children’s Research Hospital used structural biology approaches to gain insight into how sweet taste receptors detect sweeteners.

In a new study published in the BMC Biology, researchers in the Department of Organismic and Evolutionary Biology at Harvard, analyzed 156 limbs from 28 O. serratus fossil specimens to reconstruct the precise movement and function of these mysterious ancient arthropod appendages—shedding light on one of the planet’s earliest and most successful animals.