From fungi to brain cells: one scientist's winding path reveals how epigenomics shapes neural destiny
Reports and Proceedings
Updates every hour. Last Updated: 17-Jun-2026 12:16 ET (17-Jun-2026 16:16 GMT/UTC)
Dr. Maria Margarita Behrens traces her journey from South America to the Salk Institute in a Genomic Press Interview exploring brain epigenomics and the BRAIN Initiative's groundbreaking cell atlas research.
In a paper published in aBIOTECH, the authors introduce NLRSeek, a reannotation-based pipeline for comprehensive mining of nucleotide-binding leucine-rich repeat (NLR) genes in plants. NLR genes are essential for plant immunity but are frequently missed by conventional annotation methods. NLRSeek effectively recovers and identifies these overlooked genes, facilitating studies of plant defense mechanisms and the discovery of resistance gene resources.
A new study published in the Proceedings of the National Academy of Sciences finds that infant brain development during the first year of life is linked to families’ ability to meet everyday needs. Using brain activity recordings collected during routine pediatric visits, researchers found that infants whose caregivers reported significant financial hardship showed differences in brain maturation over the first year of life. The findings highlight the potential importance of policies and supports that help families meet basic needs during this critical period of early brain development.
A new study from Northwestern University provides the first empirical data showing the direct role the gut microbiome plays in shaping differences in the way the brain functions across different primate species.
A new Special Report (https://doi.org/10.1093/biosci/biaf175) published in the journal BioScience warns that long-term ecological and evolutionary research faces severe threats from lack of recurring funding and governmental/institutional support, to data manipulation and political interference, even as these studies become more crucial for addressing issues of broad societal importance, such as biodiversity loss and climate change.
Life begins with a single fertilized cell that gradually transforms into a multicellular organism. This process requires precise coordination; otherwise, the embryo could develop serious complications. Scientists at ISTA have now demonstrated that the zebrafish eggs, in particular their curvature, might be the instruction manual that keeps cell division on schedule and activates the appropriate genes in a patterned manner to direct correct cell fate acquisition. These insights, published in Nature Physics, could help improve the accuracy of embryo assessments in IVF.
Researchers at the Technion–Israel Institute of Technology have uncovered a surprising mechanism that may help explain how Alzheimer’s disease spreads through the brain. A cellular system designed to protect neurons by removing toxic proteins may, under certain conditions, actually facilitate the spread of those proteins to neighboring cells—accelerating disease progression.
The study, published in PNAS, was led by Prof. Michael Glickman, Dean of the Technion’s Faculty of Biology, together with Dr. Ajay Wagh. The researchers focused on UBB+1, a defective and toxic form of ubiquitin—a protein normally responsible for marking damaged proteins for degradation.
In healthy cells, toxic proteins are typically broken down internally. However, the team discovered that brain cells sometimes export UBB+1 outside the cell instead of destroying it. This process is mediated by p62, a protein involved in autophagy, the cell’s self-cleaning system. While p62 can direct toxic proteins to the cell’s recycling center (the lysosome), it can also package them into vesicles that are secreted into the extracellular brain fluid.
Once outside the cell, fragments of UBB+1 can leak into neighboring neurons, potentially spreading toxic protein aggregates across brain tissue. This finding may help explain how Alzheimer’s, which can begin in isolated neurons, gradually affects large regions of the brain.
“We all want someone to take out the trash,” says Prof. Glickman, “but in this case, the cells are dumping their trash on their neighbors.”
The discovery could pave the way for earlier diagnosis of Alzheimer’s through fluid biomarkers and for the development of targeted, personalized treatments.
The study was supported by the Israel Science Foundation (ISF) and the European Research Council (ERC).
Ovarian cancer often forms secondary tumors, especially in a certain tissue in the abdominal cavity known as the omentum. Researchers from the University of Basel and University Hospital Basel have investigated what happens when the cancer “hijacks” this organ. It is hoped their findings will lead to more successful treatments.