Circadian rhythms are endogenous oscillations widely present in living organisms, typically following approximately 24-hour cyclic regulation. These rhythms govern various physiological processes including sleep-wake cycles, hormone secretion, thermoregulation, and metabolism.

Diffuse Alveolar Damage (DAD), a severe pathological consequence of acute lung injury triggered by factors like infection or toxins, features intense inflammatory cell infiltration and carries a high mortality rate.

Respiratory syncytial virus (RSV) exploits host proteases to enhance its replication efficiency; however, the precise mechanisms remain unclear. Through high-throughput screening, we identified four matrix metalloproteinase 9 (MMP-9) inhibitors (including JNJ0966 and doxycycline hyclate) that suppress RSV infection in vitro and in vivo.

FDA issued guidance on April 10, 2025 to phase out animal trials in favor of organoids and organ-on-a-chip systems. This pivotal move was swiftly followed by National Institutes of Health (NIH) on April 29, when it inaugurated the Office of Research Innovation, Validation, and Application (ORIVA).

Soybean oil, the most widely consumed cooking oil in the United States and a staple of processed foods, contributes to obesity, at least in mice, through a mechanism scientists are now beginning to understand.

Researchers have decoded the signalling pathway that inhibits nerve regeneration in diabetes and have developed a therapeutic peptide that could transform the treatment—and possibly even the prevention—of diabetic nerve damage, published in Science Translational Medicine.