AI-powered cardiomyocyte ploidy assessment: CardioNVT enables high-throughput in situ analysis without immunostaining
Peer-Reviewed Publication
Updates every hour. Last Updated: 26-Oct-2026 23:16 ET (27-Oct-2026 03:16 GMT/UTC)
CardioNVT is an end-to-end deep learning platform for rapid, immunostaining-free assessment of cardiomyocyte nuclear ploidy in situ. Using only DAPI-stained heart sections, it segments cardiomyocyte nuclei, tracks them across z-stack planes, reconstructs 3D nuclear volumes, and infers ploidy from volume measurements, enabling scalable studies of cardiac development, remodeling, and repair.
A newly discovered fossil site in Egypt is reshaping scientists’ understanding of how marine ecosystems recovered after the asteroid impact that ended the Age of Dinosaurs. In a study published in Science Advances, researchers report that compositionally modern marine fish communities were already established just 4 million years after the end-Cretaceous mass extinction.
The site, known as Qreiya 3 and dated to 62.2 million years ago, preserves an exceptionally diverse offshore marine ecosystem from the early Paleocene. Hundreds of fossil fishes recovered from the site include more than 20 groups of ray-finned fishes, making it the richest and most diverse Danian fish assemblage yet discovered.
The fossils reveal that many fish groups common in today’s oceans—including early relatives of tunas, mackerels, jacks, moonfishes, and pipefishes—had already diversified shortly after the extinction event that wiped out non-avian dinosaurs. At the same time, several predatory fish groups dominant in Cretaceous seas are notably absent, suggesting a rapid ecological turnover in marine ecosystems.
Led by researchers from the Mansoura University Vertebrate Paleontology Center in collaboration with the University of Michigan and KU Leuven, the study provides some of the clearest fossil evidence yet that modern-style marine fish faunas emerged remarkably quickly after one of Earth’s greatest mass extinctions.