Tumour cells in colorectal cancer exploit an important signalling pathway that normally controls embryo development. Researchers have now shown how a protein that controls the development of the arms and heart contributes to making colorectal cancer cells more aggressive and likely to spread. By understanding these mechanisms, researchers can find ways to fight cancer without damaging vital stem cells. The study, led by researchers at Linköping University in Sweden, has been published in the journal PNAS.

POSTECH and Hanyang University Joint Research Team Develops Advanced Technology to Treat Urinary Disorders through Tibial Nerve Stimulation.

Researchers from the Institute of Industrial Science, The University of Tokyo, developed a tumor-microvessel  on-a-chip system and demonstrated that clusters of circulating tumor cells, after detaching from primary tumors, disrupt blood-vessel walls by inducing endothelial-to-mesenchymal transition. The clusters then enter the bloodstream and establish distal metastases. Targeting the ability of these clusters to disperse could help treat patients with advanced metastatic cancer.

In the latest issue of the International Journal of Extreme Manufacturing, Professor Jiankang He and his team from Xi'an Jiaotong University introduce new frontiers for the regeneration and functionality enhancement of excitable tissues by integrating bioelectronics with bioengineered constructs.

Their work not only deepens our understanding of the role of electrical microenvironments in tissue development but also sets forth critical design principles for creating bioelectronic-tissue construct hybrids. These advancements hold transformative potential for repairing and restoring damaged excitable tissues such as cardiac, neural, and muscle tissues.

Ultrastructural studies of centipede and other myriapod ovaries reveal direct soma-germline contact across the basement membrane, a structure typically regarded as a cellular barrier. These findings suggest a previously unrecognized form of interaction between somatic and germ cells in animals, challenging established views in zoology and cell biology.