A novel study has found that obesity is associated with a distinct molecular program driving the transition from early-stage, premalignant breast lesions to invasive breast cancer. Rather than simply showing increased activation of classical invasive pathways, tumors from obese patients exhibited a distinct stress-adaptive phenotype. The findings from the study in The American Journal of Pathology, published by Elsevier, suggest that metabolic health could be an important factor in future risk stratification and treatment decision-making.

The Hebrew University of Jerusalem is proud to announce that Professor Yehu Moran from the Alexander Silberman Institute of Life Sciences at the Faculty of Science has been elected as a member of the European Molecular Biology Organization (EMBO), joining a distinguished community of over 2,100 leading researchers who guide the direction of life sciences globally.

Although lung cancer is often linked to environmental exposures and acquired mutations, some patients develop multiple independent tumors, suggesting a potential role for inherited genetic susceptibility. While the contribution of germline pathogenic variants (GPVs) in several tumors is studied, their significance in lung cancer remains unknown. Now, researchers have explored the genetic basis of multiple primary lung cancers, offering  insights into novel BRCA2 GPVs which could serve as targets for therapeutic strategies.

The Hebrew University of Jerusalem proudly congratulates two of its outstanding researchers on receiving prestigious European Research Council (ERC) Proof of Concept Grants for 2026. The grants support ERC-funded researchers in translating groundbreaking discoveries into innovative applications, technologies, and services with real-world impact.

A research team led by the Universitat Autònoma de Barcelona (UAB) has revealed how the genome is reorganised in 3D during male germ cell formation in vertebrates, leading to important new insights in understanding how biodiversity is generated and maintained. The article, published in Nature Communications, analyses species with a common origin dating back over 350 million years.