European cisco – genetic adaptation to variation in salinity and spawning time
Peer-Reviewed Publication
Updates every hour. Last Updated: 21-Dec-2025 18:11 ET (21-Dec-2025 23:11 GMT/UTC)
Scientists from the University of Oslo (UiO), Akershus University Hospital (Ahus), and international partners have released a new expert opinion in Nature Aging. The article brings together more than 25 researchers from around the world, including clinicians and internationally recognised leaders in the biology of ageing and metabolism, particularly in the study of nicotinamide adenine dinucleotide (NAD⁺). Their collective perspective underscores the global effort to understand how this tiny molecule, NAD⁺, could be key to healthier ageing and protection against diseases such as Alzheimer’s and Parkinson’s.
A joint team has uncovered how soft, deformable particles, like cells, behave in microfluidic channels. Using precisely fabricated hydrogel particles and simulations on the supercomputer "Fugaku," they demonstrated that particle softness dramatically alters their focusing patterns, deviating significantly from rigid particle behavior. These findings reveal distinct "phase transitions" in focusing, shifting from mid-edge to eight-point, diagonal-edge, and finally center focusing as deformability increases. This breakthrough, explained by a new theoretical model incorporating inertia and deformability, offers crucial insights for designing next-generation microfluidic devices for highly efficient cell sorting and other biomedical applications like early cancer detection. The ability to control particle focusing based on deformability opens exciting possibilities for advanced particle manipulation and separation technologies.