Climate change is forcing amphibians to change their diet – but they can only adapt so far
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Updates every hour. Last Updated: 26-Oct-2026 05:16 ET (26-Oct-2026 09:16 GMT/UTC)
The epigenetic modifier MLL4 has a paradoxical nature: It drives disease progression in one type of leukemia but in other contexts suppresses solid tumors. Researchers used a combination of biochemistry, genetics, and structural biology to reveal surprising new characteristics that could be linked to MLL4’s unusual behavior. The findings could illuminate how the MLL4 complex helps switch genes on—including cancer genes in leukemia.
Scientists at the Department of Cell Biology of the University of Malaga have taken a step forward in the search for more effective treatments for pain with a new study that continues advancing in mitigating the addictive effects of morphine –one of the main drugs used for this purpose– as well as the development of analgesic tolerance to this drug.
A new study published in the Journal of Clinical Investigation suggests that skeletal muscle does more than power movement. Using three complementary mouse models, researchers found that two oxygen-sensing proteins, HIF1α and HIF2α, have sharply different roles in skeletal muscle physiology. HIF1α reshaped muscle fiber identity but impaired exercise performance, while HIF2α improved glucose tolerance, protected against diet-induced obesity, and unexpectedly triggered erythropoietin production from muscle tissue itself.