Historically, small molecule drugs have been precisely designed down to the atomic scale. Considering their relatively large complex structures, nanomedicines have lagged behind. Researchers argue this precise control should be applied to optimize new nanomedicines. "By controlling structure, we can create the most potent medicines with the lowest chance of adverse side effects," researcher says.

In a new study published in Science Bulletin, researchers from West China Hospital of Sichuan University present the largest human T cell reference for 68 subtypes and states, alongside STCAT, an automated annotation tool achieving 28% higher accuracy than existing methods. Their systematic analyses reveal T cell subtype dynamics in cancer and COVID-19, offering a valuable resource for the community. They also develop a TCellAtlas database for browse T cell expression profiles and analyzing customized scRNA-seq data by STCAT tool.