The Earth-Life Science Institute (ELSI) at Institute of Science Tokyo is proud to announce that it will host the PCST Japan Symposium 2025, to be held from 11–13 November 2025. This joint international symposium marks the first time the Public Communication of Science and Technology (PCST) Network brings a symposium to Japan, and the seventh conference of the Japan SciCom Forum (JSF).

♦Successful development of a stealth cloak (invisibility cloak) to protect nanomachines introduced into living organisms from foreign body reactions over extended periods: Constructed a stable ion pair network composed of polyanions and polycations on the nanomachine surface, devising a structure that prevents protein adsorption and attacks from macrophages.

♦Achieved ultra-long circulation in vivo with a half-life exceeding 100 hours after intravenous administration (10 times longer than previous stealth DDS systems).

♦Nanomachines equipped with asparaginase, an enzyme that breaks down L-asparagine, circulate long-term within the body, depleting L-asparagine—essential for cancer cell survival—from tumor tissues.

♦Confirmed the efficacy of starvation therapy for refractory breast cancer using a mouse model.

♦Furthermore, it breaks down the thick stroma (fibrous tissue) that blocks drug penetration into pancreatic cancer (such as immune checkpoint inhibitors), achieving extremely high efficacy (long-term survival) through synergistic effects with cancer immunotherapy.

♦A paper detailing the presentation content：

Junjie Li^*, Kazuko Toh, Panyue Wen, Xueying Liu, Anjaneyulu Dirisala, Haochen Guo, Joachim F. R. Van Guyse, Saed Abbasi, Yasutaka Anraku, Yuki Mochida, Hiroaki Kinoh, Horacio Cabral, Masaru Tanaka, and Kazunori Kataoka^*

Nature Biomedical Engineering (2025)

https://doi.org/10.1038/s41551-025-01534-1

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