A newly developed bioinformatics tool, MPGK, integrates Mendelian randomization, polygenic risk score, Gene Ontology, and the Kyoto Encyclopedia of Genes and Genomes pathway analyses into a unified command-line workflow. Designed to reduce the learning curve for beginners, MPGK automates complex post-genome-wide association study analyses while maintaining reproducibility and flexibility. Validation using publicly available datasets demonstrated its ability to identify disease associations and biological pathways consistent with prior research.

Cells naturally exchange cytoplasmic components like proteins, RNA, and mitochondria, but scientists lack tools to control such transfers in living cells. Now, researchers in Japan have developed a nanotube membrane-based injector—a system that enables high-efficiency, minimally invasive cytoplasmic transfer between cells. This platform preserves cell viability and can even transfer functional mitochondria, opening new possibilities for cell engineering and regenerative medicine.

A first-in-human trial from Institute of Science Tokyo and EVA Therapeutics, Inc., demonstrates that enteral ventilation, a technique that could deliver oxygen through the intestine, is safe and feasible in healthy subjects. The method involves intrarectal administration of an oxygen-carrying fluid into the gut, where oxygen may diffuse into the bloodstream. These findings provide important evidence for further testing of enteral ventilation as a potential alternative oxygenation method for patients with respiratory failure.