This study determined cryo-EM structures of midnolin-proteasome complexes, providing mechanistic insights to midnolin-catalyzed substrate degradation. Based on structural and mechanistic understanding, authors have engineered the midnolin system for targeted degradation of desired substrates, and provide the first proof-of-principle for degrading a non-native therapeutically high-profile target that is otherwise undruggable.

The reticular architecture of metal-organic frameworks (MOFs) enables not only systematic but also creative tuning of their functionalities. A recent study involving forty structurally related MOFs demonstrated how to precisely integrate and regulate two types of electrochromic cores within the MOF architectures through mild linker modifications and straightforward crystal engineering. The underlying logic is reminiscent of a conventional color palette—yet elevated to molecular-level precision, offering promising prospects for future electronic applications.

Flavanols are plant-derived compounds with an astringent taste, exhibiting pro- or antioxidant properties depending on the environment. Due to poor bioavailability, their health-promoting mechanism remains unclear. A new study identified their action via the brain-gut axis.  A single oral intake of flavanols stimulated brain regions involved in memory and sleep-wake regulation, and increased sympathetic nervous activity, a stress response. These findings may lead to future applications, such as the development of next-generation foods.

Researchers at Yonsei University developed a fluoride-based solid electrolyte (LiCl–4Li₂TiF₆) that enables all-solid-state batteries to operate safely beyond 5 volts, overcoming a major voltage stability barrier. The innovation enhances ionic conductivity, prevents interfacial degradation, and achieves record energy density. Its compatibility with cost-effective materials makes it promising for next-generation electric vehicles and renewable energy storage, marking a paradigm shift in battery technology.

A semiconductor–metal synergistic interface design via in situ engineering of a Bi/BiOCl heterostructure on Zn anodes was presented. This dual–functional heterointerface enables unprecedented electrochemical performance, including: (i) stable cycling for 2500 h at 10 mA cm^–2 in symmetric cells; (ii) 1000 cycles at 10 A g^–1 for the Zn@Bi/BiOCl//dibenzo[b,i]thianthrene–5,7,12,14–tetraone (DTT) full battery, and 15,000 cycles at room temperature and 7500 cycles at –20 °C for the Zn@Bi/BiOCl//activated carbon (AC) hybrid ion capacitor (HIC), outperforming most reported AZIBs. This breakthrough originates from a dual–functional synergy: Bi nanoparticles serve as zincophilic nucleation guides to expedite homogeneous Zn²⁺ deposition, while the BiOCl semiconductor establishes a built–in electric field with Zn to redistribute interfacial ion/charge flux and elevate the hydrogen evolution barrier. This coordinated regulation simultaneously inhibits Zn dendrite formation, HER, and Zn corrosion, imparting promising applications for Zn anodes in AZIBs. Our work not only resolves the long–standing interfacial instability of Zn anodes but also pioneers a semiconductor–metal heterojunction strategy, offering a universal platform for designing dendrite–free metal batteries operable under extreme thermal and rate conditions.