Defense or growth – How plants allocate resources
Peer-Reviewed Publication
Updates every hour. Last Updated: 1-May-2025 05:08 ET (1-May-2025 09:08 GMT/UTC)
The more a plant species invests in defense, the less potential it has for growth, according to a new study. Research made possible by open science provides new insights into plant adaptation and interspecies variation.
A research team from Oregon Health & Science University and Thayer School of Engineering at Dartmouth has developed an innovative fluorescence-guided surgery (FGS) technique using near-infrared (NIR) fluorophores to improve the identification of tumors and nerves during head and neck cancer surgeries. In a study utilizing a human HNSCC xenograft model, the researchers demonstrated that tumor-specific and nerve-specific fluorophores could be used simultaneously, allowing for real-time differentiation between cancerous tissues and critical nerves. This advancement has the potential to enhance surgical outcomes by enabling complete cancer resection while minimizing damage to surrounding healthy tissue, ultimately improving post-surgical quality of life for patients.
Collaborative research co-led by Dr. Julie St-Pierre’s lab at the University of Ottawa sheds new light on the mysteries of mitochondrial dynamics and its likely role in the metastatic progression of breast cancer – the most commonly-diagnosed cancer in women across the globe. Shapeshifting mitochondria continually fuse and divide, but precisely how those dynamics influence metastatic progression has intrigued scientists. In the work published in Science Advances, the uOttawa-led team puts forth compelling evidence that promoting mitochondrial elongation in cancer cells hobbles their ability to metastasize.
Genes contain instructions for making proteins, and a central dogma of biology is that this information flows from DNA to RNA to proteins. But only two percent of the human genome actually encodes proteins; the function of the remaining 98 percent remains largely unknown.
One pressing problem in human genetics is to understand what these regions of the genome do—if anything at all. Historically, some have even referred to these regions as “junk.”
Now, a new study in Cell finds that some noncoding RNAs are not, in fact, junk—they are functional and play an important role in our cells, including in cancer and human development. Using CRISPR technology that targets RNA instead of DNA, researchers at New York University and the New York Genome Center searched across the genome and found nearly 800 noncoding RNAs important for the function of diverse human cells from different tissues.