Syntax Bio, a synthetic biology company programming the next generation of cell therapies, today announced the publication of new research in Science Advances detailing the company’s CRISPR-based Cellgorithm™ technology, which lays the groundwork for programmable control of gene activity in human stem cells and offers an alternative to the slow, variable manual processes researchers use today.

In traditional cell differentiation, scientists expose stem cells to a series of growth factors, media changes, and environmental cues over months to coax them into a desired lineage. Each step is highly sensitive to timing and reagent conditions, leading to inconsistent results that are difficult to reproduce or scale. Syntax Bio aims to address this challenge. 

“Our research shows that we can now achieve an unprecedented level of temporal control over how genes turn on inside stem cells,” said Ryan Clarke, PhD, Syntax Bio co-founder, chief technology officer, and study co-author. “It’s the foundation of a new programming language for cells, one that we believe can eventually surpass the slow, inconsistent cell differentiation approaches researchers have relied on for years. Our goal is to make cell programming as reliable and scalable as running software.”

A University of Michigan study examined the informal economy of electronic waste recycling in Ghana.

A team from the Faculty of Physics and the Centre for Quantum Optical Technologies at the Centre of New Technologies, University of Warsaw has developed a new method for measuring elusive terahertz signals using a "quantum antenna." The authors of the work utilized a novel setup for radio wave detection with Rydberg atoms to not only detect but also precisely calibrate a so-called frequency comb in the terahertz band. This band was until recently a white spot in the electromagnetic spectrum, and the solution described in the prestigious journal Optica paves the way for ultrasensitive spectroscopy and a new generation of quantum sensors operating at room temperature.

Goldenberries taste like a cross between pineapple and mango, pack the nutritional punch of a superfood, and are increasingly popular in U.S. grocery stores. But the plants that produce these bright yellow-orange fruits grow wild and unruly—reaching heights that make large-scale farming impractical. Researchers at the Boyce Thompson Institute (BTI) helped solve that problem.