Engineered oncolytic bacteria have emerged as a promising therapeutic platform for precision cancer treatment, offering tumor-specific colonization, immune activation, and controllable therapeutic delivery. This review summarizes recent advances in the design and application of synthetic biological strategies that enhance bacterial precision, safety, and efficacy in tumor therapy. These strategies are categorized into three major regulatory modes: exogenous input–responsive gene circuits, autonomous bacterial signal–responsive gene circuits, and tumor microenvironment-responsive gene circuits.

With the rapid rise of emerging technologies such as AI, high-performance computing (HPC) and 5G, demand for improved chip performance and reliability continues to grow. A research team from City University of Hong Kong (CityUHK) has been awarded funding under the “RAISe+ Scheme” to address the complex metallisation challenges in the packaging of 3D integrated circuit (3DIC) semiconductor chips. This groundbreaking research leverages patented chemical additives in the copper electroplating process, ensuring chip performance by achieving more stable connections in stacked chips. The team plans to build an automated intelligent manufacturing line by 2026.

On December 6, 2025, the inaugural ceremony of Smart Civil Infrastructures, an international academic journal sponsored by Beijing University of Civil Engineering and Architecture (BUCEA), was grandly held during the National Bridge Academic Conference.

WASHINGTON, D.C. – U.S. Naval Research Laboratory (NRL) Engineer Shannon McGarry, Ph.D., received the Department of the Navy (DON) 2025 G. Dennis White Early Career Human Systems Integration (HSI) Practitioner Award for contributions and unwavering commitment embodying the essential qualities critical to the advancement of the HSI discipline, ensuring the safety and effectiveness of systems delivered to our warfighters.

This study explores the role of methoxy polyethylene glycol@Elabela-11 (mPEG@ELA-11), a pH-responsive ELA-11 conjugate, in modulating macrophage function and attenuating atherosclerosis, focusing on the protein kinase B (AKT)-mediated endoplasmic reticulum (ER) stress pathway as a molecular target. 

CSHL postdoc Miguel Santo Domingo Martinez and colleagues in the Lippman lab have used CRISPR gene editing to produce more compact goldenberry crops, making them easier to grow and harvest. The development could help bring this tasty fruit to farms and grocery stores around the globe.

Universidad Carlos III de Madrid (UC3M), in collaboration with the National Cybersecurity Institute (INCIBE), an entity under the Ministry for Digital Transformation and Public Administration through the Secretariat of State for Telecommunications and Digital Infrastructure, have promoted the development of a new probabilistic metric designed to more accurately measure the level of privacy and protection that users have in different databases.