A prominent research group from Ehime University and its close partner at Kiel University have published their third collaborative paper detailing PEPPI-MS, their experimental protocol combining high-resolution protein fractionation using SDS-polyacrylamide gel electrophoresis (SDS-PAGE) with the latest mass spectrometry technology to enable highly sensitive analysis of proteoforms, the diverse chemical structures of proteins. This protocol paper, published online in Nature Protocols, is expected to contribute to the development of disease diagnostics based on proteoform information.

An Osaka Metropolitan University research team developed a new experimental game to explore whether people avoid witnessing selfish behavior to evade punishing others or simply to avoid confronting unfairness. The study found that avoidance is driven by both the desire to not acknowledge inequality and the wish to prevent confrontation, suggesting that altruistic punishment may be less common in real-life situations than previously believed.

A research team provides an overview of the three prevalent biases in visual classification within Vision-Language Models (VLMs) and proposes strategies to mitigate these biases, highlighting the need for future research on debiasing in generative tasks.

A research team led by Prof. WENG Jianping from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS) revealed that insulin-like growth factor-binding protein 6 (IGFBP6) serves as a potential therapeutic target for suppressing endothelial inflammation and atherosclerosis.