Next-gen drug testing: automated zebrafish screening system for precise cardiac toxicity assessment
Peer-Reviewed Publication
Updates every hour. Last Updated: 18-Jul-2025 11:11 ET (18-Jul-2025 15:11 GMT/UTC)
A new fully automated in vivo screening system (AISS) has been developed to transform drug evaluation by enabling rapid, precise, and non-invasive multi-organ imaging in zebrafish. Integrating cutting-edge microfluidic technology with computer-vision-based control, this innovative system automates every aspect of zebrafish larvae handling— from loading and encapsulation to immobilization and drug exposure.
Empire Discovery Institute (EDI), a leading non-profit drug discovery and development accelerator, is pleased to announce the appointment of Dr. Ronald Newbold as Chief Executive Officer (CEO). Dr. Newbold, who joined EDI in 2021 as Chief Business Officer, has served as interim CEO since August 2022 and has been instrumental in driving the organization’s growth and success.
As climate change and population growth increase pressure on global food production, regional-scale crop growth and associated process (CROP-AP) models have become essential tools for understanding and predicting agricultural productivity. A new review, published in Science China Earth Sciences, categorizes these models into four types—statistical models, crop growth models, hydrology-crop coupling models, and ecosystem models. The study explores their main functions from five aspects: crop yield prediction, crop water consumption, agricultural non-point source pollution, greenhouse gas emissions, and climate change impact and responses, and identifies key future research directions, including model validation and calibration, the ability to simulate the coupling of crop physiology and human activities, enhancing model scalability, multi-model ensembles, data and code sharing, and the integration of artificial intelligence.
The first-ever published research on Tinshemet Cave reveals that Neanderthals and Homo sapiens in the mid-Middle Paleolithic Levant not only coexisted but actively interacted, sharing technology, lifestyles, and burial customs. These interactions fostered cultural exchange, social complexity, and behavioral innovations, such as formal burial practices and the symbolic use of ochre for decoration. The findings suggest that human connections, rather than isolation, were key drivers of technological and cultural advancements, highlighting the Levant as a crucial crossroads in early human history.
An international collaboration headed by researchers in the Department of Physics has shown that additive manufacturing offers a realistic way to build large-scale plastic scintillator detectors for particle physics experiments.
Conductive hydrogels from ionic liquids are widely used in soft electronics and solid electrolytes due to their high flexibility and conductivity. However, engineering such hydrogels with simultaneous biocompatibility, recyclability, excellent conductivity, stretchability, and toughness for different soft electronic applications remains challenging. This study presents a simple strategy to fabricate tough, biocompatible, and recyclable conductive hydrogels based on polyvinyl alcohol PVA and 1-butyl-3-methylimidazolium tetrafluoroborate for highly stretchable strain sensors and all-in-one supercapacitors. These hydrogels can also be recycled to make new strain sensors with consistent performance in terms of linear sensitivity, durability, and low hysteresis. This simple design concept opens up new avenues for the development of the next generation "green" wearable and implantable electronic devices.