City of Hope®, a leading cancer research and treatment organization, and Cellares, the first Integrated Development and Manufacturing Organization (IDMO), announce a collaboration focused on the City of Hope-developed IL13RA2-EGFR CAR T cell program addressing glioblastoma multiforme. City of Hope licensed this technology to Mustang Bio Inc. Under the collaboration, City of Hope will evaluate Cellares’ Cell Shuttle™ automated manufacturing platform and Cell Q™ automated quality control system to enable reliable, high-throughput manufacturing and quality control of its CARpool program. By engaging at the preclinical stage, the collaboration will establish platform processes and analytics purpose-built for solid tumor CAR T programs, accelerating advancement into clinical trials while enabling scalable manufacturing to meet global patient demand.

The partnership enables Fox Chase to become the first NCI-designated Comprehensive Cancer Center to implement clinical testing utilizing Arima's 3D-genomics technology in multiple tumor types as part of a standard protocol.

The Krainer lab discovered a three-oncogene circuit that helps drive the aggressive progression of pancreatic ductal adenocarcinoma. Using antisense oligonucleotide technology, the team developed a potential RNA therapy. In lab tests, the new treatment broke the cancerous circuit, reduced tumor viability, and triggered a type of programmed cell death.

A novel dye-sensitized photocatalyst developed at Science Tokyo enables the capture of long-wavelength visible light for efficient hydrogen conversion, surpassing conventional photocatalysts. By replacing the metal center of traditional complexes with osmium, the researchers achieved a photocatalyst that can absorb light with wavelengths beyond 600 nanometers. This shift in the absorption profile enables the system to harvest a broader range of the solar spectrum, generating more excited electrons to enhance hydrogen-evolution performance.

2D single-crystalline metal nanosheets are considered promising candidates for triboelectric nanogenerators (TENGs). Now, Researchers at Jeonbuk National University have developed a hierarchical porous copper nanosheet-based TENG that significantly improves triboelectric performance through a unique structural design. The proposed architecture provides integrated multifunctionality, including energy harvesting, electromagnetic interference shielding, and Joule heating, making it highly lucrative for next-generation wearable electronic devices.

A new spatial-adaptive active-learning workflow drastically reduces long-term testing requirements in catalyst discovery. Using only 23 synthesis experiments and 11 durability tests, the method identifies a Cu-RuO₂ catalyst that operates for 625 h at 10 mA cm⁻² in 0.5 mol L⁻¹ H₂SO₄ with an overpotential of 177 mV.

MIT engineers designed a pill that can report when it has been swallowed, an advance that could aid in medication adherence.