ENO2: a key player in head and neck squamous cell carcinoma metastasis
Peer-Reviewed Publication
Updates every hour. Last Updated: 21-Jul-2025 01:11 ET (21-Jul-2025 05:11 GMT/UTC)
A new study published in Engineering has identified enolase 2 (ENO2) as a key factor in the lymphatic metastasis of head and neck squamous cell carcinoma (HNSCC). The research reveals how ENO2 and its metabolite phosphoenolpyruvate (PEP) promote cancer cell invasion and macrophage polarization, and shows that inhibiting ENO2 can potentially slow down HNSCC metastasis.
An estimated 240 million calls are made to 911 in the U.S. each year, with wireless devices accounting for 80% or more of these calls. Making sure emergency calls connect and stay connected to 911 dispatchers is essential and could have life-threatening consequences. MSU researchers found that in certain situations, 90% of emergency wireless calls failed to connect to 911 within 120 seconds but have developed an app to correct this.
Guan-Hua “Scott” Tu, an associate professor in the College of Engineering, and his team observed that despite sufficient wireless signal coverage, users may still experience prolonged emergency call setup times, call initiation failures, or call drops.
Researchers have discovered a groundbreaking use of terahertz (THz) imaging to visualize cochlear structures in mice, offering non-invasive, high-resolution diagnostics. By creating 3D reconstructions, this technology opens new possibilities for diagnosing hearing loss and other conditions. THz imaging could lead to miniaturized devices, like THz endoscopes and otoscopes, revolutionizing diagnostics for hearing loss, cancer, and more. With the potential to enhance diagnostic speed, accuracy, and patient outcomes, THz imaging could transform medical practices.