Engineers create digital twin of gut-brain axis to advance neurostimulation therapies
Peer-Reviewed Publication
Updates every hour. Last Updated: 30-Oct-2026 14:17 ET (30-Oct-2026 18:17 GMT/UTC)
Researchers at Lehigh University have developed one of the first comprehensive digital twins modeling the neural circuitry between the gut and brain. Funded by the NIH SPARC program, this quantitative computer model simulates how electrical signals travel via the vagus nerve to regulate digestion. By accurately modeling communication breakdowns that cause disorders of gut-brain interaction (DGBI)—such as irritable bowel syndrome and gastroparesis—the digital twin enables scientists to virtually test and optimize invasive and non-invasive neurostimulation therapies before advancing to costly animal and human clinical trials.
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