Early-stage disease diagnosis relies on the highly sensitive detection of biomarkers. Optical whispering-gallery-mode (WGM) microcavity sensors have emerged as a highly promising technology for precise, label-free biosensing. However, major challenges remain in the rapid fabrication of large-scale arrayed WGM microcavity sensors and their integration into lab-on-a-chip devices for biomedical applications. In a noteworthy advance, researchers at The Hong Kong Polytechnic University (PolyU) have developed a novel 3D micro-printed WGM microlaser sensor for highly sensitive on-chip biosensing. This innovation drives the development of next-generation biosensing tools, enabling direct, ultrasensitive and quantitative measurement of biomarkers for early disease detection.