Energy researchers discover part of electron that drives catalysis
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Updates every hour. Last Updated: 23-Nov-2025 20:11 ET (24-Nov-2025 01:11 GMT/UTC)
Two distinct stem cell lineages that drive tooth root and alveolar bone formation have been identified by researchers from Science Tokyo. Using genetically modified mice and lineage-tracing techniques, the team shed light on the cell signaling mechanisms guiding differentiation in stem cells in the developing teeth, offering key insights for future regenerative dental therapies.
On October 7, 2025, Karlsruhe Institute of Technology (KIT) celebrates its anniversary. On the same day, exactly 200 ago, Ludwig I, Grand Duke of Baden, signed the founding decree for the Karlsruhe Polytechnic School, the first predecessor institution of today’s University of Excellence. The Grand Duke founded it out of his “concern for the education of our dear and loyal bourgeoisie.” Today, KIT is a place where science is shaping the future by contributing energy, mobility, and climate research as well as robotics and artificial intelligence.
ChatGPT has not decreased activity on the world’s largest online encyclopaedia, but AI data scrapers and the influence of Large Language Models still cast a shadow over its future research suggests.
A research team from the USC Norris Comprehensive Cancer Center, in collaboration with City of Hope, has found a promising way to adapt CAR T cell therapy so that it can fight solid tumors. The researchers engineered CAR T cells to produce a fusion of two proteins: interleukin 12 (IL-12) cytokine, which boosts immune activity, and a programmed death-ligand 1 (PD-L1) blocker, an immune checkpoint inhibitor that prevents cancer cells from turning off the immune attack. In mouse models of prostate and ovarian cancer, the modified CAR T cells launched a localized attack, shrinking the tumor without causing toxicity in other parts of the body. The results were just published in the journal Nature Biomedical Engineering. The approach enhanced the ability of T cells to penetrate tumors and made the surrounding environment less hostile. It was also safe, with minimal toxicity elsewhere in the body, making it an attractive therapy to translate to patients.
New research published in Nature Ecology & Evolution sheds light on the timelines and pathways of evolution of fungi, finding evidence of their influence on ancient terrestrial ecosystems. The study, led by researchers from the Okinawa Institute of Science and Technology (OIST) and collaborators, indicates the diversification of fungi hundreds of millions of years before the emergence of land plants.