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Updates every hour. Last Updated: 15-Jun-2026 01:16 ET (15-Jun-2026 05:16 GMT/UTC)
Fighting highway subgrade settlement on the roof of the world
Tsinghua University PressPermafrost degradation on the Qinghai-Tibet Plateau is accelerating under climate warming, causing roadbed settlement, waterlogging, thawing interlayers, and long-term instability in high-altitude highways. The study reviews global and Chinese permafrost engineering practices, identifies the mechanisms behind pervasive subgrade deformation, and highlights challenges in current “permafrost-protection” design approaches. It proposes a third design principle — proactively improving foundation conditions — advancing from passive protection to active treatment. The work further summarizes shallow and deep foundation treatment techniques, evaluates engineering applications, and outlines development trends such as improved hydrological investigation, long-term monitoring, and novel construction materials.
- Journal
- Journal of Highway and Transportation Research and Development (English Edition)
A DIY, fly-powered fix for food scraps
University of California - Riverside- Journal
- Waste Management
Dual engineering of catalyst and sacrificial agent for efficient photo-biocatalytic CO2 reduction
Higher Education PressAn efficient and highly selective NADH regeneration system has been constructed by integrating M with CIS microspheres via facile electrostatic self-assembly with L-AA as a sacrificial agent.
- Journal
- Acta Physico-Chimica Sinica
3D printing revolutionizes mass spectrometry
Shanghai Jiao Tong University Journal CenterMass spectrometry (MS) is an analytical technique for molecular identification and characterization, with applications spanning various scientific disciplines. Despite its significance, MS faces challenges in widespread adoption due to cost constraints, instrument portability issues, and complex sample handling requirements. In recent years, 3D printing has emerged as a technology across industries due to its cost-effectiveness, customization capabilities, and rapid prototyping features. This review explores the integration of 3D printing with MS technology to overcome existing limitations and enhance biomedical analysis capabilities. We first categorize mainstream 3D printing methods and assess their potential in MS applications. We also discuss their roles in different MS categories such as liquid chromatography mass spectrometry (LCMS), gas chromatography mass spectrometry (GCMS), ambient ionization mass spectrometry (AIMS), and matrix-assisted laser desorption/ionization MS (MALDI MS) in biomedical research. Additionally, we highlight the current challenges and future research directions for advancing 3D printing-assisted mass spectrometry, emphasizing its role in enabling portable, cost-effective, and customized MS solutions for biomedical analysis.
- Journal
- LabMed Discovery
Transforming tumor diagnostics with CRISPR/Cas
Shanghai Jiao Tong University Journal CenterPrecise tumor diagnosis and treatment require the support of abundant molecular information. However, conventional molecular diagnostic technologies gradually fail to satisfy the demands of clinical therapy due to limited detection performance. Benefiting from highly specific target sequence recognition and efficient cis/trans cleavage activity, CRISPR/Cas system has been widely employed to construct novel molecular diagnostic strategies, hailed as the “next-generation molecular diagnostic technology”. This review focuses on recent advances in CRISPR molecular diagnostic systems for the detection of tumor variant gene, protein, and liquid biopsy biomarker, and outlines strategies for CRISPR in situ molecular detection. In addition, we explore general principles and development trends in the construction of CRISPR molecular diagnostic system and emphasize the revolutionary impact that it has brought to the field of molecular diagnostics.
- Journal
- LabMed Discovery
Applications to pan-semiconductor manufacturing: galvanometer-based alignment-error-free full-in-situ imaging and laser processing system
Higher Education PressNo calibration, no alignment errors: A new laser system images and machines in one step, carving precise shapes in circuits and weeding out bad micro-LEDs with better than 15 µm accuracy—read how it works.
- Journal
- Engineering
Investigation on three-dimensional unsteady flow characteristics during TBCC inlet mode transition using fast-responding PSP
SciOpenThe mode transition of combined-cycle inlets, governed by sidewall constraints, is inherently characterized by significant three-dimensional (3D) unsteady flow phenomena that elude capture by conventional two-dimensional (2D) diagnostics or single-point transducers. This research published in the Chinese Journal of Aeronautics utilizes fast-response pressure-sensitive paint (PSP) to conduct dynamic measurements on the wall pressure field of a typical over-under TBCC inlet during mode transition, successfully elucidating the 3D characteristics of these unsteady flows.
- Journal
- Chinese Journal of Aeronautics