In a recent study, Dr. Chander Negi, a postdoctoral research associate in the lab of Texas A&M University professor Dr. Ivan Rusyn, investigated how an emerging “liver-on-a-chip” technology compares with traditional testing methods used in drug safety evaluation.

Over the past several years, monitoring the transmission fitness of emerging SARS-CoV-2 variants has been critical for pandemic forecasting and public health response. However, existing methods, such as basic reproductive number estimation or phylogenetic analysis, often face limitations in directly comparing variants that dominate at different times or in quantifying their relative advantages with robustness to sampling biases. Thus, developing a data-driven, comparative framework to estimate relative variant fitness and visualize evolutionary trends across time and geography is of paramount importance.

Comorbidity—the co-occurrence of multiple diseases in a patient—complicates diagnosis, treatment, and prognosis. Understanding how diseases connect at a molecular level is crucial, especially in aging populations and complex conditions like COVID-19, where comorbidities worsen outcomes. While network medicine has used the human interactome—a map of protein-protein interactions—to study these links, accurately predicting comorbid pairs remains challenging.

 

Kyoto, Japan -- Whether you practice ballet or prefer the tango, the benefits of dancing are self-evident. It's good exercise both physically and mentally due to the complexity of the movements, and it's also a fun social activity. But the benefits of dancing may extend beyond this: the mental activity and social interaction involved in dancing may also help prevent cognitive decline.

Previous research indicates that dance practice can improve the cognitive test scores of older adults with mild cognitive impairment, or MCI, an intermediate state of cognitive decline between normal aging and dementia. This inspired a team of researchers from Kyoto University to extend this research to older adults in an earlier stage of cognitive decline called subjective cognitive decline, or SCD. This refers to an individual's self-reported worsening memory or increased confusion that cannot yet be verified by tests.

"We focused on SCD because earlier intervention is more important from the viewpoint of dementia prevention," says first author Masatoshi Yamashita.

Endoplasmic reticulum (ER) stress and the unfolded protein response are often implicated in the progression of metabolic dysfunction-associated steatotic liver disease (MASLD), from simple steatosis to inflammation-driven metabolic dysfunction-associated steatohepatitis and, ultimately, hepatocellular carcinoma. A new review paper from Hanyang University ERICA sheds light on the mechanisms underlying these processes, advocating for precise hepatic ER stress control to maintain normal hepatocyte function and develop therapeutic strategies against MASLD.

A multinational research team led by Professor Tong Zhang from the Department of Civil Engineering, Faculty of Engineering at The University of Hong Kong (HKU Engineering), in collaboration with an international team, has developed a new framework to assess and track antimicrobial resistance (AMR) connectivity across human, animal, and environmental sectors. The study systematically examines the connectivity of AMR and proposes an assessment framework along with mitigation strategies.