In the paper published on Science of Traditional Chinese Medicine (STCM), the authors employed UPLC-MS/MS technology and elucidated the processing principle of rhubarb pieces based on in vivo profile of components. This study comprehensively analyzed the dynamic in vivo changes of prototype anthraquinones and their glucuronide metabolites in rhubarb from the perspectives of absorption, distribution, and excretion. It proposed that processing can reduce the exposure of components, achieve targeted distribution in the intestine, and accelerate the excretion of components, thereby clarifying the processing mechanism of 'raw rhubarb purges while steamed rhubarb moderates'. This provides a solid research perspective for the study of the processing principles of traditional Chinese medicine.

Researchers have fabricated GO-wrapped TiO₂ (GOx@TiO₂) hybrid particles at room temperature by an electrostatic self-assembly process. The construction of GO_0.005@TiO₂ and the bimodal 1G59B filler as bimodal inorganic fillers is a new approach for achieving high-strength dental composites.

POSTECH researchers develop a bio-implant with virtually no immune response at the cellular and tissue level.

To investigate the role of KIF13B in SICD, a research team led by Prof. Xunde Xian from Peking University conducted a series of experiments using mouse models of sepsis and cultured cardiomyocytes.

Impaired mitophagy and the accumulation of damaged mitochondria are key drivers of endothelial cell (EC) dysfunction in diabetic wounds. While mitochondrial transplantation (MT) has demonstrated therapeuticpotential in such mitochondrial damage-related diseases, its application is still thwarted by elusive mechanisms and practical hurdles such as poor targeting specificity and low delivery efficiency. Here, wereveal that MT acts by reactivating mitophagy to selectively eliminate dysfunctional mitochondria, therebyrestoring mitochondrial homeostasis and rescuing EC functionality. To exploit this discovery, we engineer abiomimetic MT strategy through coating EC-derived apoptotic vesicle membrane (AVM) onto the surfaceof isolated mitochondria. The resulting mitochondria–AVM complex (Mito-AVM) leverages homologoustargeting and phosphatidylserine-mediated “eat-me” signaling, achieving a remarkable 150% increasein delivery efficiency to ECs in diabetic wounds. Furthermore, we construct a 3-aminophenylboric acid-modified hyaluronic acid/polyvinyl alcohol hydrogel for the diabetic wound microenvironment, enablingreactive oxygen species/glucose-triggered sustained release of encapsulated Mito-AVM at the wound site. In summary, our work elucidates a fundamental mechanism of MT and provides an efficient and targetedstrategy for MT therapy, offering fresh perspectives for diabetic wound treatment.

The research findings have been published in Research under the title "Apoptotic Vesicle Membrane-Mediated Targeted Endothelial Mitochondrial Transplantation-Clearance Therapy for Diabetic Wound Healing."

Allergen immunotherapy is entering the era of precision medicine. Instead of treating all allergy patients according to the same scheme, doctors can now tailor therapy to an individual’s molecular allergy profile and specific disease mechanisms. Thanks to modern diagnostics and biomarkers, it is becoming possible to distinguish true allergy from cross-reactivity, better predict treatment effectiveness, and improve patient safety. According to Prof. Marek Jutel from Wroclaw Medical University, allergology is moving toward highly personalized causal treatment, although wider implementation still requires further research, standardization, and broader access to advanced diagnostics.