Shandong University researchers develop multi‑scale feature fusion and weighted ensemble learning method for accurate promoter identification across cell lines
Peer-Reviewed Publication
Updates every hour. Last Updated: 23-Oct-2026 17:17 ET (23-Oct-2026 21:17 GMT/UTC)
Promoters are key DNA regions that control gene transcription, but their activity varies greatly across different cell types. This heterogeneity makes it difficult for existing computational methods to identify promoters reliably. A team led by Professors Zhangyu Mei and Hao Wu from Shandong University, China, has developed MuSE‑Promoter, a deep ensemble learning framework that combines multi‑scale feature fusion, transformer attention, and a learnable weighted ensemble of neural network and random forest. The system outperforms state‑of‑the‑art methods on human cell lines from different tissues and on Arabidopsis thaliana datasets, and shows excellent generalization in cross‑cell‑line and promoter–enhancer discrimination tasks.
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