Researchers at the University of Waterloo have uncovered new insights into how estrogen protects against high blood pressure, a condition affecting more than one billion people worldwide. Using an advanced mathematical model of the cardiovascular and kidney systems, a team led by Anita Layton, Canada 150 Research Chair Laureate in Mathematical Biology and Medicine, found that estrogen’s ability to relax and widen blood vessels (vasodilation) plays the most significant role in reducing hypertension risk. The model also suggests that angiotensin receptor blockers may be more effective than ACE inhibitors for treating women with high blood pressure after menopause. The findings, published in Math Biosci., support more tailored and equitable approaches to women’s health care.