No bowel preparation for colonoscopy achieves optimal efficacy and tolerability. Combining polyethylene glycol plus ascorbic acid with adjuvants has been explored to enhance cleansing efficacy and reduce the required volume. This study aimed to evaluate whether adding 0.5 mg linaclotide improves superior cleansing compared to adding 24 mg senna.

Storm surges—sudden, abnormal rises in sea levels during storms—pose a major threat to low-lying coastal communities. Some of the most extreme sea levels occur during major tropical cyclones, when harsh winds and low atmospheric pressure drive ocean waters higher.  

Currently, there is a strong scientific consensus on the long-term changes of mean sea-level rise that is supported by tide gauge observations and data-informed modeling.  However, estimates of extreme storm surge trends in these events have been inconsistent and largely constrained to studies analyzing tide gauge data from a limited number of locations.  These limitations hinder scientists’ ability to evaluate how extreme storm surge events may respond to climate variability and change, thereby complicating the development of cost-effective strategies for coastal flood adaptation.  In a recent study(Link is external) conducted by the University of Central Florida, Princeton, Rutgers and four other research centers, researchers analyzed tide gauge data from across the U.S. to better identify trends in extreme storm surges.