A new strategy for synthesizing polyfunctionalized biaryls without transition-metal catalysts
Peer-Reviewed Publication
Updates every hour. Last Updated: 29-Oct-2026 18:16 ET (29-Oct-2026 22:16 GMT/UTC)
Researchers at the Institute of Science Tokyo have developed a simple and efficient method for synthesizing polyfunctionalized biaryls without transition-metal catalysts or complex multistep prefunctionalization. Through an innovative substrate design strategy, the researchers achieved a benzidine-type sigmatropic rearrangement of nitroarenes that efficiently produces the desired biaryls in high yields. This approach offers precise control over the reaction pathway, enabling the synthesis of diverse organic compounds, thereby benefiting many industries.
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