The analysis of over 6,400 research articles shows a significant rise in studies on hydrothermal pretreatment, with China leading the global research output. The findings underscore the potential of this green technology for converting lignocellulosic biomass into biofuels and bioproducts.

CAMBRIDGE, Mass., January 23 --- Insilico Medicine( “Insilico”) , a clinical stage generative artificial intelligence (AI)-driven biotechnology company today announced the first patient has been dosed in the global multicenter Phase I Trial of ISM6331, a novel pan-TEAD inhibitor developed from Insilico's generative chemistry engine Chemistry42, for the treatment of mesothelioma and other solid tumors. Currently, ISM6331 is the leading oncology program among Insilico's wholly owned AI-driven drug discovery pipelines, which was granted orphan drug designation (ODD) by the FDA for the treatment of mesothelioma.

Until a few years before her death, it was unthinkable that laser specialist Gisela Eckhardt, inventor of the Raman laser, would one day bequeath about €11.5 million to Goethe University Frankfurt. After all, Eckhardt had turned her back on the university with resentment after completing her doctorate here in 1958 and emigrating to the U.S. Sixty years later, however, the erstwhile physics student designated “her” Goethe University as her heir, thereby laying the foundations for an endowed professorship in experimental physics – to which solid-state physicist Prof. Olena Fedchenko was appointed this month. The city of Frankfurt has honored the late laser pioneer by naming one of the squares in its Bockenheim district after Gisela Eckhardt. Fedchenko will give her inaugural lecture as part of the honorary celebrations on January 30.

Inductively coupled plasma mass spectrometry (ICP-MS) is prominently used for analyzing elemental composition in individual cells. However, the conventional sample introduction system of ICP-MS causes damage to large mammalian cells. Now, researchers from Japan suggest an efficient method of introducing mammalian cells using a microdroplet generator (µDG) that maintains the cell’s structure without compromising elemental composition. These findings can open new avenues for the diagnosis and prognosis of diseases.

Oral mucositis is a painful condition in which the mucous membranes inside the mouth become inflamed. To help alleviate this, researchers at the Tokyo University of Science (TUS) have developed a mucoadhesive film using xyloglucan and antioxidant-rich green tea extract containing catechins. With its strong adhesive properties, the film directly adheres to the affected area. Made from accessible ingredients, this solution could provide localized relief and improve the quality of life for patients.