Operando X-ray tomography reveals silicon–electrolyte interface dynamics in all-solid-state batteries
Peer-Reviewed Publication
Updates every hour. Last Updated: 6-May-2026 11:16 ET (6-May-2026 15:16 GMT/UTC)
Silicon anodes can greatly boost the energy density of all-solid-state batteries, but their large volume changes often cause contact loss with solid electrolytes. Using operando synchrotron X-ray micro- and nano-computed tomography, researchers at Ritsumeikan University directly visualized the 3D evolution of the silicon–electrolyte interface during charge and discharge cycling. They found that even as silicon expands and shrinks, the thin, solid-electrolyte layers remain adhered, preserving partial ion pathways and enabling stable operation.
While scientists have made significant progress in understanding how nerve cells transmit signals across their outer membranes, Marucho’s team is focused on what happens inside the cell, within the cytoskeleton. The cytoskeleton is a network of structures located within a cell’s cytoplasm that is composed of actin filaments and microtubules.
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Professor Dongsheng Liu of Tsinghua University, Professor Ziyang Hao of Capital Medical University, and Researcher Yuanchen Dong of the Institute of Chemistry, Chinese Academy of Sciences, have collaborated to develop a circular single-stranded DNA molecule capable of simultaneously silencing multiple miRNAs. This molecule can be used for multi-gene synergistic tumor therapy. Based on the KIMU principle, the circular single-stranded DNA molecule, an anti- miRNA oligonucleotide (circAMO), can be synthesized with high selectivity and high yield by adjusting the length of the DNA clamp. The unique covalently closed circular structure endows circAMO with high biostability, allowing long-term intracellular gene regulation without any chemical modifications. By designing multiple miRNA binding sites in circAM, one circAMO can simultaneously inhibit multiple oncogenic miRNAs and upregulate the levels of downstream mRNAs, ultimately inhibiting tumor cell proliferation, migration, and invasion, as well as increasing apoptosis. This strategy provides a new research tool and platform for multi-target gene therapy. The article was published as an open access research article in CCS Chemistry, the flagship journal of the Chinese Chemical Society.