Using AI to optimize hydrogen fuel production and reduce environmental impact: Worcester Polytechnic Institute research published in Nature Chemical Engineering
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A new metal–organic framework (MOF), APF-80, enables the crystalline sponge method to capture and analyze nucleophilic compounds. Alkaloids, a diverse group of biologically active compounds, usually damage MOF crystals and resist study. By incorporating multiple structural motifs, these guests are encapsulated inside APF-80, which allows high-quality crystallographic data collection. This development opens new possibilities for structural analysis, advancing drug development and biochemistry.
Arsenic leaking from abandoned gold mines can harm forest ecosystems by entering soils and affecting soil organisms. In a recent study, researchers tested forest soils with different chemical properties to see how they influence arsenic mobility and toxicity in springtails. Results showed juveniles were more sensitive to mobile arsenic, while adults responded to total arsenic. These findings highlight the importance of soil chemistry and life stage in arsenic risk assessment.
Researchers at Harvard and Northwestern have developed a machine learning method that can design intrinsically disordered proteins with custom properties, addressing nearly 30% of all human proteins that are currently out of reach of AI tools like AlphaFold. The new approach uses automatic differentiation, traditionally a deep learning tool, to optimize protein sequences for desired properties.