16-Feb-2026
Trapping a single protein in a molecular cage: A new path to drug discovery for ALS
National Institutes of Natural SciencesPeer-Reviewed Publication
Proteins often function in pairs or groups, concealing their internal connection points and making it difficult for scientists to study their individual units without altering their natural structure. Researchers successfully isolated single units of the protein SOD1, which is linked to Amyotrophic Lateral Sclerosis (ALS), by chemically tagging the protein and encapsulating it within tiny, self-assembled artificial cages. This technique exposed the normally hidden interface of the protein, allowing the team to identify specific compounds like quercetin that bind to these regions, offering a promising new strategy for finding drugs that inhibit disease-causing protein aggregation.
- Journal
- Journal of the American Chemical Society
- Funder
- JSPS Grants-in-Aid for Specially Promoted Research, JSPS Grants-in-Aid Early-Career Scientists, JST PRESTO, Joint Research of the ExCELLS, Japan Science Society, Iketani Science and Technology Foundation, Platform Project for Supporting Drug Discovery and Life Science Research [Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)] from AMED, MEXT NMR Platform, MEXT Promotion of Development of a Joint Usage/Research System Project: CURE, JSPS Research Fellowship for Young Scientists