Why are some people unable to hear from birth, even though their inner ear appears intact? One possible cause lies in the so-called OTOF gene. It plays a central role in transmitting sound signals from the hair cells to the auditory nerve. Without this function, acoustic information does not reach the brain. Researchers from the German Primate Center – Leibniz Institute for Primate Research, the University Medical Center Göttingen, and the Max Planck Institute for Multidisciplinary Sciences have now, for the first time, generated marmosets in which this gene has been knocked out precisely. The animals are healthy and develop normally, but are deaf from birth. This provides the first primate model that realistically replicates key characteristics of human deafness.

Researchers at the Josep Carreras Leukaemia Research Institute have demonstrated that combining data from different origins enables a more precise characterisation of cell type’s diversity into tissues and organs. The team also introduced scOMM, a new machine learning tool for classifying and compare cell types across the distinct data modalities. The tool is openly available to researchers worldwide and has been successfully tested in kidney tissue, one of the most cellularly diverse organs in the human body and validated in blood and heart tissue. As the results demonstrate, when it comes to understanding complex tissues, the whole is greater than the sum of its parts.

Microbial metabolites influence health far beyond the intestinal tract. Yet, a systematic understanding of how these molecules precisely control specific immune cell functions and regulate disease has remained elusive. A comprehensive review by the team of Professor Changtao Jiang and Dr. Kai Wang at Peking University addresses this gap. The article provides a critical theoretical foundation for understanding the gut microbiota-metabolite-immune axis in disease pathogenesis and for developing targeted intervention strategies.

A collaborative research study co-led by scientists at the Icahn School of Medicine at Mount Sinai and the Liber Institute for Brain Development has for the first time identified a biological process that may help explain how the brain develops differently in people with Down syndrome.

Researchers at the Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences (CAAS), have engineered a high-fidelity adenine base editor variant, ABE8eY149V, to overcome the severe genome-wide off-target risks associated with the hyperactive ABE8e. Through comprehensive genome-wide off-target analysis by two-cell embryo injection (GOTI), the team first revealed that ABE8e induces massive sgRNA-independent single-nucleotide variants (SNVs), nearly 30-fold higher than spontaneous background levels. 

Researchers at the Wuhan Institute of Virology have decoded a critical survival strategy of the deadly Nipah virus (NiV), identifying a key host protein hijacked by the pathogen and translating this discovery into a promising new treatment approach. The work, published in Protein & Cell, addresses the urgent need for therapies against this high-mortality virus, for which no specific drugs currently exist.

Kyoto, Japan -- "It takes a village to raise a child" doesn't apply merely to humans. Many species of mammals, birds, fish, and various invertebrates have evolved complex social care systems known as cooperative breeding. In these animal societies, offspring receive attention not only from their parents but also from other group members called helpers.

Such social systems have evolved independently multiple times across various taxa, yet most studies have focused on birds and mammals. After studying fish in Lake Tanganyika, one of Africa's great lakes bordering four countries, a team of researchers at Kyoto University was inspired to investigate the forces behind cooperative breeding in lamprologine cichlid, a fish variety endemic to the lake. Specifically, they aimed to elucidate the evolutionary history of cooperative breeding and its correlation with the life history traits of several of these species.

"I have long been interested in how animals cooperate with other individuals," says first author Shun Satoh. "Even when social systems appear superficially similar, the environmental factors that promoted increasing social complexity may have differed among mammals, birds, and fish, and I find that especially fascinating."

Researchers at Hiroshima University have developed a new tool to quickly and accurately map fungal gene functions, even for species that have never been studied before.

Researchers identified the tegmentum in the midbrain as an ‘integration center’ of fish. The area receives visual information from the eyes that is combined with color information detected by the pineal organ—the ‘third eye.’ These inputs are integrated to control how fish orient themselves in the water.