A review in Neuroprotection (2026) reconceptualizes Parkinson’s disease as a lifelong neurobiological process shaped by early-life vulnerability, cumulative environmental exposures, and resilience factors. The authors integrate developmental biology, epigenetics, neuroimmune mechanisms, and brain plasticity into a prevention-focused framework. They highlight how early risks and lifelong protective behaviors influence disease trajectory, while emphasizing the need for longitudinal studies, early biomarkers, and targeted interventions to enable prevention rather than late-stage treatment.

Shi Yuankai’s team’s review on EGFR-TKIs for NSCLC (2000–2026) came out in the Chinese Medical Journal. Lung cancer leads in global cancer incidence/mortality, with NSCLC as the main subtype and EGFR a key driver. EGFR-TKIs are core for advanced EGFR-mutant NSCLC, with expanded clinical applications and prolonged patient survival. Yet EGFR-TKI resistance is a big challenge; the review summarizes its 2000–2025 development and future directions.

How food is shared inside ant colonies has long been invisible in real time. Researchers in Japan have now used a highly sensitive radioactive imaging technique to watch food move from ant to ant, minute by minute. The method reveals unexpected patterns in how resources spread through a group and could help scientists detect early warning signs of stress or imbalance in insect societies, crucial to ecosystems and agriculture.

Ependymoma is a central nervous system tumor that occurs primarily in children and can arise in the supratentorial region, posterior fossa, or spinal cord. Although molecular classification has substantially improved disease stratification and prognostic assessment, the metabolic phenotypes associated with the major pediatric subtypes have remained poorly defined. Because pediatric ependymoma is rare, assembling a cohort that spans multiple molecularly defined subtypes for systematic metabolic comparison is itself challenging.

Diabetes is a highly prevalent chronic condition and a major contributor to the global burden of disease, posing substantial challenges to health systems. Cardiovascular disease (CVD) remains its leading complication, and people with diabetes face a two- to four-fold higher risk of cardiovascular morbidity and mortality than the general population. Control of glycated hemoglobin (HbA1c), blood pressure, and low-density lipoprotein cholesterol (LDL-C), collectively referred to as ABC risk factors, is a cornerstone of cardiovascular prevention in diabetes.

Scientists from the National University of Singapore have successfully engineered a naturally occurring beneficial gut bacterium into a programmable “living medicine” to treat hepatic encephalopathy (HE), a severe brain dysfunction linked to liver failure. The therapy combines two engineered gut-bacteria strains: one absorbs excess gut ammonia and converts it into nutrients lacking in HE patients, while the other reduces ammonia production. Compared with a standard HE antibiotic, the cocktail achieved stronger improvements in anxiety and short-term memory, while also reduced inflammation in the brain.