Chinese researchers assembled the first gap-free telomere-to-telomere (T2T) reference genome for Glycyrrhiza uralensis, plus high-quality chromosome-scale genomes for two other pharmacopoeia licorice species. Population multi-omics of 188 wild licorice accessions identified the GiPHL1-Gi4CL5 regulatory module that controls licochalcone A production and drought adaptation in G. inflata. This work delivers key genomic resources for licorice molecular breeding and sustainable utilization.

Mitochondrial transplantation is emerging as an organelle-level therapeutic strategy for diseases associated with mitochondrial dysfunction. A new Perspective in Science Bulletin discusses how engineered mitochondrial delivery systems may improve mitochondrial stability, targeting, and clinical translation.

What if cells that form scars after a spinal cord injury could become part of the repair process? Researchers have developed a genetic system that converts certain scar-forming cells into neurons, improving movement in mice and rats with spinal cord injuries.

A three-herb formula (Ganoderma lucidum, Rhodiola rosea, Paecilomyces hepiali) restored immune function in rats kept under simulated microgravity and then challenged with bacteria. Inflammation fell and the spleen stayed intact, with NF-κB/RelA, a switch that drives inflammation, held in check. This study provides a new approach for developing functional foods suitable for use during long-duration spaceflight.