Liver organoids with proper blood vessel networks have been successfully produced, as reported by researchers from Institute of Science Tokyo and Cincinnati Children’s Hospital Medical Center. This advancement addresses a major challenge in replicating the liver’s complex vasculature in lab-grown tissues. Using a novel 3D culture system, the researchers achieved the self-organization of four distinct precursor cell types into functional organoids, capable of producing essential clotting factors in a haemophilia A mouse model.

Airborne microorganisms, including fungi and bacteria, are major contributors to indoor air pollution, with growing links to respiratory diseases. In a recent study, scientists from Korea explored the health effects of common airborne microbes by testing their toxicity in mice and calculating human-equivalent exposure limits. The results revealed that some fungi can cause lung inflammation and injury even at concentrations below current guideline levels, highlighting the need for species-specific indoor air quality standards.

How is ventilation at various depth layers of the Atlantic connected and what role do changes in ocean circulation play? Researchers from Bremen, Kiel and Edinburgh have pursued this question and their study has been published in the professional journal Nature Communications.

Researchers have extracted a novel polysaccharide fraction named AJDW from the flower of Albizia julibrissin Durazz. (AJD). AJDW could not only inhibit the growth and proliferation of pancreatic cancer in vitro and in vivo, but also suppress pancreatic cancer migration, block cell cycle and induce ROS-mediated apoptosis by reducing mitochondrial membrane potential linked to PI3K/Akt/mTOR signaling pathway.